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염증유발 백서에서 전침자극과 Meloxicam gel 적용이 유해성굴곡반사 및 체성감각유발전위에 미치는 효과
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  • 염증유발 백서에서 전침자극과 Meloxicam gel 적용이 유해성굴곡반사 및 체성감각유발전위에 미치는 효과
저자명
김영필,이정우,서삼기,윤세원,윤희종,김태열,Kim. Young-Pil,Lee. Jeong-Woo,Seo. Sam-Ki,Yoon. Se-Won,Yoon. Hee-Jong,Kim. Tae-You
간행물명
대한임상전기생리학회지
권/호정보
2007년|5권 1호|pp.45-58 (14 pages)
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대한임상전기생리학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

This study aims to examine the effects on nociceptive neuron excitability by application of electroacupuncture and Meloxicam gel in rat with inflammation. It used 24 rats for experiment, divided them into control group, electroacupuncture group(EA group), Meloxicam group(ME group), combination of electroacupuncture with Meloxicam group(EA+ME group), caused hyperalgesia by injecting ${lambda}$-carrageenan into hindpaw and conducted treatment three times for experimental period. Noxious flexion withdrawal reflex(NFR) and somatosensory evoked potential(SEP) were measured immediately after induction, at 24 hours, 48 hours and 72 hours after induction. Change of NFR(reaction time, RMS) showed no significant differences among EA group, Meloxicam group, and EA+Meloxicam group, but all treatment groups showed significant differences compared to control group from 48 hours. In NFR threshold, there were significant differences between EA+Meloxicam and other groups. In SEP amplitude, there were significant differences between EA+Meloxicam and control group from 48 hours. This study showed that EA+Meloxicam gel had an effect on nociceptive neurone excitability. Therefore, it is considered that appropriate combination of anti-inflammatory drug with electroacupuncture for pain control will be very desirable.