This paper analyses the effect of parameters on the consequences of the unconfined vapor cloud explosion accident (UVCE) by the release of heavy gas (xylene vapor). Simulation results showed that the overpresure was increased with the increase of the release hole diameter and with the decrease of the interested distance and the wind speed. While, the overpresure was not nearly affected by the release height, weather and environmental conditions. From the results of the consequence analysis and analysis of affecting the consequences of UVCE, the emergency plan should be established taking into account these parameters.