Objectives: There is a perception that a total laryngectomy has a devastating effect on patients and their families, but only a few studies have addressed long-term quality of life (QOL) after laryngectomy. Materials and Methods: A cross-sectional study of 32 patients more than 3 years since laryngectomy was performed. Patients were asked to complete the SF-36 questionnaire before surgery and within 3-5 years after surgery. Preoperative and postoperative SF-36 scores were compared with data on 46 age-matched healthy controls. Results: The most of SF-36 subscale scores showed significant deterioration after surgery. Preoperative scores had significantly poorer than the normal controls on 6 subscales, and also postoperative scores was lower than normal controls on 2 subscales. Conclusion: In the study, the quality of life of the patients who underwent total laryngectomy show poorer scores than pre operative status and normal controls.