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개 간손상(肝損傷)에 대한 소시호탕(小紫湖湯)의 회복효과(回復效果)
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  • 개 간손상(肝損傷)에 대한 소시호탕(小紫湖湯)의 회복효과(回復效果)
  • Recovery Effect of Xiao Chai Hu Tang (So Si Ho Tang) on the Hepatic Injury in Dogs
저자명
김태경,김상훈,전형규,윤효인,조성환,김덕환,Kim. Tae-Kyung,Kim. Sang-Hoon,Jun. Hyung-Kyou,Yoon. Hyo-In,Cho. Sung-Whan,Kim. Duck-Hwan
간행물명
Journal of veterinary clinics
권/호정보
2007년|24권 2호|pp.164-168 (5 pages)
발행정보
한국임상수의학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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This study was performed to establish the recovery effect of So Si Ho Tang on hepatic injury in dogs. Clinically healthy eight dogs (1-3 yrs old, 3-5 kg) were divided into control group (n=3) and experimental group (50 mg/kg, n=5). Hepatic injury was induced by administration of $CCl_4$ in all groups. Control group was received no treatment after hepatic injury and experimental group was orally administered with So Si Ho Tang at a dose of 50 mg/kg. The change of serum ALT and AST activities was examined before hepatic injury and on day 0, day 5 and day 12 after administration of So Si Ho Tang. Histopathologic examinations were performed on day 12. As a result, significant changes in serum ALT were found on day 5(p<0.05) and day 12(p<0.05), compared with those of control group, respectively. In addition, significant change in serum AST was found on day 1 (p<0.05) and day 5 (p<0.05), compared with those of control group, respectively. In histopathologic examination, mild hemorrhage and fatty degeneration and vacuolization were observed in experimental group in contrast to those of control group. Accordingly, it was suggested that administration of So Si Ho Tang was effective for hepatic injury induced by $CCl_4$ in dogs.