Purpose: The purpose of this study is to analyze the smoking behaviors and to identify the impacts of depression, temperament, and characteristic on smoking experience in the female adolescents. Methods: This study surveyed 691 highschool girls in the Gangwon area using self -administered questionnaires. Data were analyzed by SPSS 12.0. using Pearson correlation coefficient and multiple regression. Results: The smoking rate of the highschool girls was lower than that of the national average. Depression was observed to be seriously in the highschool girls. There were a positive correlations among smoking experience, the school records and novelty seeking and a negative correlation between smoking and cooperativeness. The significant predictors of smoking experience were the type of school, the satisfaction with school the school records, novelty seeking, reward dependence and cooperativeness. Conclusion: These results suggest that femalel adolescents who have the factors identified in this study are considered to have the potential for smoking. These results provide the basis for developing smoking prevention and cessation programs.