Purpose: The purpose of this study was to identify the factors influencing drinking problems in female university students to provide basic data for a nursing intervention program to improve health and prevent drinking problems. Method: Data were collected from September 17 to 21, 2007 through a questionnaire survey of 325 female college students in G City. Collected data were analyzed using descriptive statistics, pearson correlation coefficients and stepwise multiple regression. Result: The most powerful predictor of drinking problems was refusal self efficacy. The combination of the influence of friends, perceived stress, personality of novelty seeking, and alcohol expectancy accounted for 23.7% of the variance in drinking problems. Conclusion: From the results, I recommend that refusal self efficacy, influence of friends, perceived stress, personality of novelty seeking, and alcohol expectancy should be contained in developing nursing intervention programs for preventing drinking problems in female university students.