In this study, computational structural vibration analyses of a smart unmanned aerial vehicle (SUAV) with tilt-rotors due to dynamic hub loads have been conducted considering detailed supporting structures of installed equipments. Three-dimensional dynamic finite element model has been constructed for different fuel conditions and tilting angles corresponding to helicopter, transition and airplane flight modes. Practical computational procedure for modal transient response analysis is successfully established. Also, dynamic loads generated by rotating blades and wakes in the transient and forward flight conditions are calculated by unsteady computational fluid dynamics technique with sliding mesh concept. As the results of present study, transient structural displacements and accelerations of the vibration sensitive equipments are presented in detail. In addition, vibration characteristics of structures and installed equipments of which safe operation is normally limited by the vibration environment specifications are physically investigated for different flight conditions.