As facing the rapid advance of information technologies, the postal service is required to have capabilities of real-time logistics characterized by collaboration, ubiquity and intelligence which are necessary to the organizational management. In this study we discuss the design of the next generation information system based on real-time enterprise strategy to achieve real-time integrity and upgrade of postal information system. After briefly addressing the issues on developing information system and current situation, we provide the design direction and the framework of the to-be system. We develop detailed specification of each subsystem and provide an operational scenario. We believe when this framework is put into use, it can contribute to competitive performance by giving the integrity and consistency in implementing information systems of the Korea Postal Service.