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An Efficient Functional Analysis Method for Micro-array Data Using Gene Ontology
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  • An Efficient Functional Analysis Method for Micro-array Data Using Gene Ontology
  • An Efficient Functional Analysis Method for Micro-array Data Using Gene Ontology
저자명
Hong. Dong-Wan,Lee. Jong-Keun,Park. Sung-Soo,Hong. Sang-Kyoon,Yoon. Jee-Hee
간행물명
International journal of information processing systems
권/호정보
2007년|3권 1호|pp.38-42 (5 pages)
발행정보
한국정보처리학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Microarray data includes tens of thousands of gene expressions simultaneously, so it can be effectively used in identifying the phenotypes of diseases. However, the retrieval of functional information from a large corpus of gene expression data is still a time-consuming task. In this paper, we propose an efficient method for identifying functional categories of differentially expressed genes from a micro-array experiment by using Gene Ontology (GO). Our method is as follows: (1) The expression data set is first filtered to include only genes with mean expression values that differ by at least 3-fold between the two groups. (2) The genes are then ranked based on the t-statistics. The 100 most highly ranked genes are selected as informative genes. (3) The t-value of each informative gene is imposed as a score on the associated GO terms. High-scoring GO terms are then listed with their associated genes and represent the functional category information of the micro-array experiment. A system called HMDA (Hallym Micro-array Data analysis) is implemented on publicly available micro-array data sets and validated. Our results were also compared with the original analysis.