This study investigates how characteristics in the value-chain industrial cluster affect the R&D investment and the output of firms in each industries. For this, we try to extract the inter-industrial networking structure from the input-output table in which 17 manufacturing sectors are included. In particular, we will give shape to the "unit structure" which shows the intermediary flows of goods and services between industries in order to get an unit of final demand in a certain industry. Using this "unit structure", we can try the inter-industrial networking analysis and get some indices of centrality and centralization related to the characteristics of each industries in the value-chain industrial cluster. The results show that the centrality in the value-chain industrial cluster does not have any consequence for the R&D investment and the output in each industries. However, there is a correlation between the centralization in the value-chain industrial cluster and the R&D investment and the output of firms in each industries. These results may be very suggestive in bringing up a new frame of industrial cluster policy in a macro level.