An impeller is a important part of turbo-machinery. It has a set of twisted surfaces because it consists of many blades. Five-axis machining is required to produce a impeller because of interference between tool and workpiece. It can obtain good surface integrity and high productivity. This paper proposes finish cutting method for machining impeller with 5-axis machining center and optimization of cutting condition by response surface method. Firstly, cutting methods are selected by consideration of operation characteristics. Secondly, response factors are determined as cutting time and cutting error for prediction of productivity. Experiments are projected by central composite design with axis point. Thirdly, regression linear models are estimated as single surface in the leading edge and as dual surface in the hub surface cutting. Finally, cutting conditions are optimized.