This paper focuses on providing a practical approach for decision making in Performance-Based Design (PBD). Satisfactory performance is defined by several performance objectives that place limits on direct (monetary) loss and on a tolerable probability of collapse. No specific limits are placed on conventional engineering parameters such as forces or deformations, although it is assumed that sound capacity design principles are followed in the design process. The proposed design procedure incorporates different performance objectives up front, before the structural system is created, and assists engineers in making informed decisions on the choice of an effective structural system and its stiffness (period), base shear strength, and other important global structural parameters. The tools needed to implement this design process are (1) hazard curves for a specific ground motion intensity measure, (2) mean loss curves for structural and nonstructural subsystems, (3) structural response curves that relate, for different structural systems, a ground motion intensity measure to the engineering demand parameter (e.g., interstory drift or floor acceleration) on which the subsystem loss depends, and (4) collapse fragility curves. Since the proposed procedure facilitates decision making in the conceptual design process, it is referred to as a Design Decision Support System, DDSS. Implementation of the DDSS is illustrated in an example to demonstrate its practicality.