Seismic design codes are developed mainly based on the observation of the behavior of structures in the high seismicity regions where structures may experience significant amount of inelastic deformations and major earthquakes may result in structural damages in a vast area. Therefore, seismic loads are reduced in current design codes for building structures using response modification factors which depend on the ductility capacity and overstrength of a structural system. However, structures in low seismicity regions, subjected to a minor earthquake, will behave almost elastically because of the larger overstrength of structures in low seismicity regions such as Korea. Structures in low seismicity regions may have longer periods since they are designed to smaller seismic loads and main target of design will be minor or moderate earthquakes occurring nearby. Ground accelerations recorded at stations near the epicenter may have somewhat different response spectra from those of distant station records. Therefore, it is necessary to verify if the seismic design methods based on high seismicity would he applicable to low seismicity regions. In this study, the adequacy of design spectra, period estimation and response modification factors are discussed for the seismic design in low seismicity regions. The response modification factors are verified based on the ductility and overstrength of building structures estimated from the farce-displacement relationship. For the same response modification factor, the ductility demand in low seismicity regions may be smaller than that of high seismicity regions because the overstrength of structures may be larger in low seismicity regions. The ductility demands in example structures designed to UBC97 for high, moderate and low seismicity regions were compared. Demands of plastic rotation in connections were much lower in low seismicity regions compared to those of high seismicity regions when the structures are designed with the same response modification factor. Therefore, in low seismicity regions, it would be not required to use connection details with large ductility capacity even for structures designed with a large response modification factor.