RFID is an emerging technology and rapidly applied to various industries due to its high-tech characteristic and convenience. Although RFID provides valuable benefits. it might also generate serious privacy problems. Previous studies show that privacy issues should be incorporated in developing RFID systems and more detailed privacy protection methods. However. they just provide basic concept, rough guideline. and simple architecture about RFID privacy protection. Industry needs more structured framework and detailed systematic process to incorporate privacy issues into the RFID system. The purpose of this paper is to develop a framework and detailed process design of RFID privacy protection issues in retail industries. A framework is developed based on individual sensitivity concept, RFID contents, and interface with EPC global standard. Case study is applied to validate the framework and it turns out to be useful. It is expected that the proposed framework and process design would provide more systematic guide lines to solving RFID privacy problems.