Cheyletiellosis is a very common infestation in pet rabbits that causes dermatosis with pruritus and scale. In this study, thirty two rabbits with cheyletiellosis were treated with a single dermal application of a formulation containing imidacloprid 10% (w/v) and moxidectin 1% (w/v) at a dose 0.4 ml. The therapeutic effects of the formulation were 100% at 4, 8 and 12 weeks without adverse reactions. This suggests that a formulation containing imidacloprid and moxidectin is an effective treatment for cheyletiellosis in rabbits.