Ketorolac tromethamine gel (KT gel) and ketorolac tromethamine gel containing genipin (KTG gel) were prepared and their therapeutic effects on periodontitis were evaluated. The skin permeation rate of ketorolac from the KT gel and KTG gel was $5.75{pm}0.53$ and $5.82;{pm};0.74;{mu}g/cm^{2}/h$, respectively. The skin permeation rate of genipin from the KTG gel was $10.13;{pm};1.47;{mu}g/cm^2/h$. The tensile strength of the KTG gel was larger than the KT gel. After 4 weeks, the periodontal pocket depth of the KTG gel group ($3.22;{pm};0.20;mm$) significantly decreased compared with the non-treated group ($4.50;{pm};0.25;mm$) and the KT group ($3.84;{pm};00.26;mm$). The KTG gel did not induce separation of the stratum corneum and subcutaneous tissue, and the collagen layers of the cerium were closer, more fibrous, and showed longer connections than in the other groups. The KTG gel appears to be effective against gingivitis in the periodontal pocket through its increased anti-inflammatory activity and the crosslinking of genipin with the biological tissue.