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정전가미이진탕(正傳加味二陳湯)이 흰쥐의 위배출능(胃排出能)에 미치는 영향(影響)
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  • 정전가미이진탕(正傳加味二陳湯)이 흰쥐의 위배출능(胃排出能)에 미치는 영향(影響)
  • Effect of Jungjungamiyjintang(JGT) on Gastric Emptying of Spregue-Dawley rat
저자명
김회영,손현수,임성우,남효익,Kim. Hoi-Young,Son. Hyun-Soo,Lim. Sung-Woo,Nam. Hyo-Ik
간행물명
대한한방내과학회지
권/호정보
2007년|28권 2호|pp.209-216 (8 pages)
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대한한방내과학회
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Background & Objective : The herbal medicine JGT has been used for the treatment of functional dyspepsia, generally categorized as a gastric disease. However, its effect and mechanism are not yet well known. Therefore, the effects of JGT on gastric emptying in rats was investigated to know its effectiveness and mechanism. Methods : Gastric emptying effect was measured by the number of glass beads expelled from the stomach within an hour after glass beads and test drugs were administered. In another series of experiments to evaluate the mechanisms of JGT under delayed conditions, the rats were treated with atropine sulfate Results : Intragastric administration of JGT significantly increased gastric emptying of glass beads Under the gastric emptying delayed with atropine sulfate, JGT insignificantly increased gastric emptying of glass beads. Conclusions : These suggest that JGT has a significant effect to stimulate gastric emptying. Results are indicative of JGT as an especially effective remedy for dysmotility-like functional dyspepsia with impaired reservoir function such as gastric adaptive relaxation.