Objectives : This research ws performed to investigate the effect of manual acupuncture at TE4, SP3 and TE4+SP3 on body weight, blood glucose, BUN, creatinine, lipid metabolism, liver function and morphological change of hepatic tissue in hyperglycemia rats. Methods : Experimenal groups were divided into hyperglycemia group(Control group), hyperglycemia and acupuncture therapy group at SP3, hyperglycemia and acupuncture therapy group at TE4, hyperglycemia and acupuncture therapy group at TE4+SP3 , once per 2 days during 5 weeks. Results : Body weight was decreased significantly in TE4 group of fifth week compared with Control group. Blood glucose was decreased significantly in SP3 group compared with control group. Creatinine was decreased significantly in TE4 and TE4+SP3 group compared with control group. Total cholesterol was decreased significantly in TE4+SP3 group compared with control group. Triglyceride was decreased significantly in TE4 gorup compared with control group. In the morphological change of hepatic cell, TE4 and SP3 group were showed he rough endoplasmic reticulum forms aggregates of parallel, flattened cisternae scattered randomly throughout the cytoplasm compared with control gruop. Conclusions : Acupuncture at TE4 can manage hyperglycemia by controlling body weight, and lipid metabolism in hyperglycemia rats induced by streptozotocin.