Objectives The purpose of this study is to examine of the effect of Sachunghwan on the liver disease. Methods It was induced liver damage rats by thioacetamide and dosed the extract orally and measured the activity rate of GOT, GPT, ALP and LDH. Results 1. GOT activity was more decreased in the experimental goup than in the control goup. Group I showed continuous significance after 72 hour, Group II was significance after 96 hours. 2. GPT activity was more decreased in the experimental group than in the control group. Group I was effective after 72 hours, but group II was effective after 96 hours. 3. The significance of ALP activity in the Group I and group II was revealed after 72 hours. 4. The significance of LDH activity in the Group I and group II was revealed after 96 hours. Conclusions It was showded that Sachunghwan extract was effective on liver disease.