In this letter, we address the problem of resource allocation with efficiency and quality of service (QoS) support in uplink for a wireless CDMA network supporting real-time (RT) and non-realtime (NRT) communication services. For RT and NRT users, there are different QoS requirements. We introduce and describe a new scheme, namely, traffic aided uplink opportunistic scheduling (TAUOS). While guaranteeing the different QoS requirements, TAUOS exploits the channel condition to improve system throughput. In TAUOS, the cross-layer information, file size information, is used to improve fairness for NRT users. Extensive simulation results show that our scheme can achieve high system throughput in uplink wireless CDMA systems, while guaranteeing QoS requirements.