This work studies the impact of five parameters: CO and HC engine-out emissions, space velocity, average value and profile of exhaust temperature, on Diesel CO and HC tail-pipe emissions. The first part of this work is conducted on a reactor and shows that both HC and CO light-off temperature increases with CO and HC input concentration. CO and HC initial concentration influence the adsorption/desorption capacities of HC only at high temperatures. Space velocity also influences CO and HC conversion efficiency. The second part of this work studies the impact of different combinations of HC and CO engine-out emissions on CO and HC conversion and tail-pipe emissions in the case of New European Driving Cycle. This part proposes that a Diesel oxidation catalyst must be mainly studied at the Urban Part of NEDC, as the CO and HC conversions are very high at the extra-urban part of NEDC. CO and HC conversion efficiencies are also dependent on exhaust temperature and catalytic volume. In the case of two different profiles of exhaust temperature with the same average temperature, CO and HC conversion efficiency is lower in the case of the smoother profile.