The vibration of a vehicle, which is caused by and transmitted from the engine, has significant effect on the ride comfort and the dynamic characteristics of the engine mount system have direct influence on the vibration and noise of the vehicle. This paper examines the body shake caused by the engine excitation force on engine key on/off of a medium truck by experiment and simulation. The analysis model consists of the engine, a body including the frame, front and rear suspensions and tires. The force element between the body and the suspension is modeled as a combination of a suspension spring and a damper. The engine shake obtained from the experiment was compared with the result of the computer simulation, and by using the verified computer model, parametric study of the body shake on engine key on/off is performed with changing the stiffness of an engine mount rubber, the engine mount angle, and the position of engine mounts.