Natural gas has been considered one of the most promising alternative fuels for transportation because of its abundance as well as its ability to reduce regulated pollutants. We measured emission characteristics of nanoparticles from lean burn H/D(Heavy-Duty) CNG (Compressed Natural Gas) engine equipped with oxidation catalysts. The experiments were carried out to measure the emission and engine performance according to the ESC test cycle. The CO and THC conversion efficiencies on the best catalyst in the ESC test cycle achieved about 91 % and 83 %, respectively. From the measurement by the SMPS, the number of nanoparticles emitted from H/D CNG engine is reduced by about 99 % which is more than that of 2.5 L diesel engine. The particle number concentrations of H/D CNG engine were almost nanoparticles. Nanoparticles smaller than 30 nm emitted from the H/D CNG engine and diesel engine equipped with a CDPF(Catalyzed Diesel Particulate Filter) were quite similar. However, the particles bigger than 30nm from the CNG engine were smaller than the particles from diesel engine equipped with a CDPF. The higher the CNG engine load, the lower the particle number from engine-out, but it increased slightly at full load.