Let V be an arbitrary system of weights on an open connected subset G of ${mathbb{C}}^N(N{geq}1)$ and let B (E) be the Banach algebra of all bounded linear operators on a Banach space E. Let $HV_b$ (G, E) and $HV_0$ (G, E) be the weighted locally convex spaces of vector-valued analytic functions. In this paper, we characterize self-analytic mappings ${phi}:G{ ightarrow}G$ and operator-valued analytic mappings ${Psi}:G{ ightarrow}B(E)$ which generate weighted composition operators and invertible weighted composition operators on the spaces $HV_b$ (G, E) and $HV_0$ (G, E) for different systems of weights V on G. Also, we obtained compact weighted composition operators on these spaces for some nice classes of weights