Highly pathogenic avian influenza(HP AI) is one of the most important zoonoses in the around of world. That occurred in the domestic ducks of 34 olds day in Jeonbuk of Korea on April 2008. All of infected ducks were died. We could found several clinical signs such as facial swelling with cloudy eyes, conjunctivitis, and neurological sign. In the autopsy, moderate congestion in the kidney, multifocal hemorrhagic foci in pancreas, and mild swelling in brain were observed. Gliosis in brain and severe congestion in kidney were also shown in histopathological findings. Specific band for H5 antibody was detected in polymerase chain reaction (PCR).