In this study, the possibility of vibration control of high-rise building structures by applying top-story isolation has been investigated. To this end, El Centro NS (1940) earthquake load is applied to 20- and 50-story building structures for numerical analysis. Artificial wind loads are used to evaluate the serviceability of example structures against wind vibration. As the number of isolated stories of example buildings is changed, structural responses has been evaluated to investigate optimal isolated building mass. And the natural period of isolation systems for top-story isolation is varied to investigate the improvement of control performance compared with the fixed base structure. Based on the analytical results, the top-story isolation system can be used as a hued mass damper and effectively reduce the structural responses of high-rise buildings against wind and seismic loads.