In engineering application of large eddy simulation, there are still questions as follows grid dependency on numerical results, the effect of upwind scheme against a calculation instability, appropriate boundary conditions dealing with turbulence fluctuation and the performance of SGS models. In this study, in order to develop the LES to the engineering application, large eddy simulation was carried out to investigate the effect of upwind scheme, turbulent subgrid model and the grid dependancy of the flow around a wall-mounted cube in a channel at Re=40,000 based on cubic height and bulk mean velocity. The computed velocities, turbulence quantities, separation and reattachment length were evaluated compared with the experimental results of R. Matinuzzi and C. Tropea.