When operating a complex facility, Fault Detection and Diagnosis (FDD) system is beneficial in equipment management by providing the operator with tools which can help find out a failure of the system. In this research, FDD algorithm was developed using the general pattern classifier method that can be applied to centrifugal chiller system. The simulation model for a centrifugal chiller system was developed in order to obtain characteristic data of turbo chiller system under normal and faulty operation. We tested FDD algorithm of a centrifugal chiller using data from simulation model at full load performance and 60% part load performance. In this research, we presented fault detection method using a normalized distance. Sensitivity analysis of fault detection was carried out with respect to fault progress. FDD algorithm developed in this study was found to indicate each failure modes accurately.