Working condition is one of the most important factors in precision working. In this study, we optimized the vibration acceleration of working progress direction using RSM(response surface methodology) by table of orthogonal array. RSM was well adapted to make analytic model for minimizing vibration acceleration, created the objective function and saved a great deal of computational time. Therefore, it is expected that the proposed optimization procedure using RSM can be easily utilized to solve the optimization problem of working condition. The experimental results of the surface roughness and vibration acceleration showed the validity of the proposed working condition of side wall end-milling as it can be observed.