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Activation of Adenosine A2A Receptor Impairs Memory Acquisition but not Consolidation or Retrieval Phases
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  • Activation of Adenosine A2A Receptor Impairs Memory Acquisition but not Consolidation or Retrieval Phases
  • Activation of Adenosine A2A Receptor Impairs Memory Acquisition but not Consolidation or Retrieval Phases
저자명
Kim. Dong-Hyun,Ryu. Jong-Hoon
간행물명
Biomolecules & therapeutics
권/호정보
2008년|16권 4호|pp.320-327 (8 pages)
발행정보
한국응용약물학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Several lines of evidence indicate that adenosine $A_{2A}$ agonist disrupts spatial working memory. However, it is unclear which stages of learning and memory are affected by the stimulation of adenosine $A_{2A}$ receptor. To clarify these points, we employed CV-1808 as adenosine $A_{2A}$ agonist and investigated its effects on acquisition, consolidation, and retrieval phases of learning and memory using passive avoidance and the Morris water maze tasks. During the acquisition phase, CV-1808 (2-phenylaminoadenosine, 1 and 2 mg/kg, i.p.) decreased the latency time in passive avoidance task and the mean savings in the Morris water maze task, respectively. During the consolidation and retrieval phase tests, CV-1808 did not exhibited any effects on latency time in passive avoidance task and the mean savings in the Morris water maze task. These results suggest that CV-1808 as an adenosine $A_{2A}$ agonist impairs memory acquisition but not consolidation or retrieval.