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Characterization of Dexamethasone-eluting PLGA Films Coated on Capsular Tension Ring to Prevent Posterior Capsule Opacification
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  • Characterization of Dexamethasone-eluting PLGA Films Coated on Capsular Tension Ring to Prevent Posterior Capsule Opacification
  • Characterization of Dexamethasone-eluting PLGA Films Coated on Capsular Tension Ring to Prevent Posterior Capsule Opacification
저자명
Chang. Byung-Kon,Kim. Bo-Gyun,Kim. Young-Jae,Kang. Myung-Joo,Lee. Jae-Hwi,Choi. Young-Wook
간행물명
Biomolecules & therapeutics
권/호정보
2008년|16권 4호|pp.425-430 (6 pages)
발행정보
한국응용약물학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The objectives of this study were to prepare PLGA film onto the surface of the capsular tension ring (CTR) for controlled drug release and investigate the influence of plasticizers, the test drug and measurement conditions on flexibility of the film. Film solutions were prepared by dissolving PLGA, plasticizer (triethyl citrate, TEC or polyethylene glycol, PEG), test drug (dexamethasone) in ethyl acetate then films were prepared by spray coating and evaporation method. Then, the flexibility of PLGA film was determined by elongation test. The addition of plasticizer, PEG or TEC to PLGA copolymer caused a depression of glass transition temperature ($T_g$) and the elasticity of PLGA films increased. The addition of dexamethasone to the PLGA/TEC matrix decreased the flexibility of film. Dimensional factors of the PLGA films such as width and thickness were significantly influenced on flexibility of films and film length and elongation speed had no considerable influence on elongation of films. In this study, sufficiently flexible and stable PLGA films capable of being coated onto CTR could be prepared. This PLGA films can be used as a platform for local drug delivery.