This study was to develope the pesticide-proof clothes(PPC) for fruit-grower which has been well known over applied agricultural chemicals. The ergonomic evaluation of PPC were tested in two ways. Male adults volunteered the tests to evaluate the safety to pesticide in the field and the thermal comforts in the climate-chamber($30^{circ}C$, 60%R.H.). PPC were made of 4 different fabrics. Two of them were on the market(coated non-woven and coated nylon). Others were water-repellent treatment and coated waterproof film by developed polyester. The field study was conducted for farmers growing apples to evaluate pesticide exposure. In this experiment, we collected data with patch test on the head, chest, back, right upperarm, right forearm, left thigh and left calf. From the results, the developed PPC showed the more excellent comfort than an existing PPC with nylon coated polyurethane. But the developed PPC of water-repellent fabric was penetrated into the PPC. Therefore, we designed the functional pesticide-proof clothes of 2 different developed polyester fabrics(water-repellent treatment in chest, abdomen, the lower of back, waist, and calf; coated waterproof film in head, shoulder, the upper of back, the crotch, hip, upper arm and thigh).