In this study, it is outlined that heavy weight floor impact noise induced by the vibration of slab can be reduced using multi tuned mass damper(MTMD) effectively. Substructure synthesis is utilized to develope analytical model of the slab coupled with MTMD and acoustic power is introduced to evaluate the performance of noise control for simplicity. Numerical analysis is carried out to investigate the effect of the properties of MTMD on the vibration and noise control of the simply supported slab. Numerical analysis shows that mass ratio of MTMD is critical on the vibration and noise control of the slab and it is also essential to reduce the vibration in higher modes of slab in the light of its great effect on the radiation of sound.