With ever increasing number of citizen using subway stations everyday, safety, health and comfort of passengers and occupants (mostly metro personnel) have become important social issues. Considering the fact that various physical variables and pollutants such as particulate, VOCs and biological agents are closely related to indoor air quality (IAQ) which may cause health problems, a method of quantitative assessment using information-theoretic measure on such variables needs to be devised and implemented for comfort, health and safety of passengers and occupants in the subway station. A basic framework for assessing indoor air quality (for comfort and health) and safety in subway station is suggested. In particular, application of information-theoretic measure for the assessment of indoor air quality, comfort and safety in subway station is discussed. Some examples are presented as well.