In this paper, in order to set up the management system of water quality environment in Gwangyang Bay, the cluster analysis of water quality environment, the estimation of inflowing pollutant loads and residence time of pollutants in this bay was carried out. The Gwangyang Bay was divided into eight sea areas by cluster analysis and spatio-temporal change of water quality. The river discharges in the Bay were calculated about $11,681{ imes}103m^3/day$ from the numerical simulation by Tank model. In addition, inflowing pollutant loads of COD, SS, TN, TP, DIN and DIP in Gwangyang Bay were estimated at 398 ton-COD/day, 2,846 ton-SS/day, 195 ton-TN/day, 5 ton-TP/day, 126 ton-DIN/day and 3 ton-DIP/day, respectively. Moreover, residence times of COD, TN and TP in the Bay was estimated at 6 days-COD, 20 days-TN and 195 days-TP, respectively in the dry season, and 3 days-COD, 6 days-TN and 21 days- TP, respectively, in the flood season. The central part of Gwangyang Bay (Region IV) has the longest residence time of overall pollutants.