Generally, hiccup is a temporary symptom, however, persistent or intractable hiccup that repeats continuously or does not respond to medical treatments makes the patients very painful. In this case, a seventy-two years old patient with pontine infarction showed symptoms as aspiration pneumonia and persistent hiccup a few days after hospitalized. We considered him as excess heat pattern and prescribed Yangkyuk-san. In the result, not only the frequency and intensity of hiccup were remarkably decreased but also the inflammation and overall symptoms by pontine infarction were improved.