In this paper, the Post Process for the manifold complex processing using CAD/CAM Software of two and a half Dimensions(2.5D) has been developed to maximize the application of the manifold manufacturing machine. Many companies are currently making use of high price systems to improve manufacturing process using the multi-axial complex manufacturing machine. In accordance with the requirements, the utilization of CAD/CAM Software for the manifold complex manufacturing machine is earnestly demanded. However, the experts who have experience in manifold manufacturing machine are insufficient. Consequently the outcomes of the Post Process for 2.5D CAD/CAM Systems have been dealt in order to be smoothly operated by those who have basic skills and be understood in process drawings. CNC program functions can be specially used as they are, when drawn up. The Post Process for the original point designation and transformation of coordinates has been developed and applied. The results gave proof of practical manufacturing outcomes.