In this study, the influence of reaction temperatures, mixing time and flexible modifier for crumb rubber modified asphalt(CRMA) as processing conditions were investigated. The temperature susceptibility and adhesion properties of neat and modified asphalts at low temperature measured using the penetration and tensile adhesion test. It was found that processing temperatures and flexible modifier were important factors for tensile adhesion strength and toughness energy at low temperature. The CRMA in the higher processing temperature and flexible modifier exhibited improved tensile adhesion properties which indicated the flexible structure of neat and modified asphalt binder. In general, the improvements of the physical properties in the CRMAs were due to the improvements of miscibility between CR and asphalt binder. It was found that the adhesion properties of the flexible agent modified CRMA were higher than CRMA were related to the flexible agent tend to penetrate into CR particles and asphalt binder.