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GC/MS를 이용한 소변 중 대마 대사체 분석의 측정불확도 평가
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  • GC/MS를 이용한 소변 중 대마 대사체 분석의 측정불확도 평가
  • Uncertainty Evaluation of the Analysis of 11-Nor-9-carboxy-${Delta}^9$-tetrahydrocannabinol in Human Urine by GC/MS
저자명
김진영,정재철,서승일,서용준,이정직,김종상,인문교,Kim. Jin-Young,Jeong. Jae-Chul,Suh. Sung-Ill,Suh. Yong-Jun,Lee. Jeong-Jik,Kim. Jong-Sang,In. Moon-Ky
간행물명
약학회지
권/호정보
2008년|52권 6호|pp.480-487 (8 pages)
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대한약학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

We described an estimation of measurement uncertainty in quantitative analysis of 11-nor-9-carboxy-${Delta}^9$-tetrahydrocannabinol (THCCOOH), the major metabolite of ${Delta}^9$-tetrahydrocannabinol, in urine sample by solid-phase extraction (SPE) and GC/MS detection. The analytical results were compared and the different contributions to the uncertainty were evaluated. Inter-day and inter-person validation were performed using statistical analysis of several indicative factors. Measurement uncertainty associated with target analyte in real forensic samples was estimated using quality control (QC) data. Traceability of measurement was established through traceable standards, calibrated volumetric glassware and volume measuring device. The major factors of contribution to combined standard uncertainty, were calibration linearity, inter-day repeatability and inter-person reproducibility, while those associated with preparation of analytical standards and sampling volume were not so important considering the degree of contribution. Relative combined standard uncertainties associated with the described method was 12.05% for THCCOOH.