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Determination of Enantiomeric Impurity of Etodolac by Capillary Electrophoresis using (2-Hydroxypropyl)-$eta$-cyclodextrin
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  • Determination of Enantiomeric Impurity of Etodolac by Capillary Electrophoresis using (2-Hydroxypropyl)-$eta$-cyclodextrin
  • Determination of Enantiomeric Impurity of Etodolac by Capillary Electrophoresis using (2-Hydroxypropyl)-$eta$-cyclodextrin
저자명
Dung. Phan Thanh,Ko. Mi-Young,Choi. Hyun-Ju,Sin. Kwan-Seog,Kim. Kyeong-Ho
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2008년|31권 9호|pp.1218-1223 (6 pages)
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대한약학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

A capillary electrophoresis method was developed to determine the impurity of etodolac enantiomers. (2-Hydroxypropyl)-$eta$-cyclodextrin (HP-$eta$-CD) was used as a chiral selector and ketoprofen as an internal standard to improve the peak area precision. The seperation of the etodolac enantiomers was achived within 35 min at $15^{circ}C$ and its highest resolution was about 4.0 using phosphate buffer (0.1 M, pH 6.0) with 15 mM HP-$eta$-CD and UV detection at 225 nm with a reference wavelength at 360 nm. This method allowed determination of 0.2% of (R)-(-)-etodolac in (S)-(+)-etodolac and method validation showed adequate linearity over the required range.