A transient 3-D numerical simulation was performed to analyze the fire safety in a railway tunnel equipped with a mechanical ventilation system. The behavior of pollutants was studied for the emergency operation mode of ventilation system in case of fire in the center of the rescue station and near the escape route. Various schemes of escape route construction for connection angle($45^{circ}$, $90^{circ}$, 135^{circ}$) and slope($10^{circ}$) were evaluated for the ventilation efficiency in the fire near the escape route. From the results, it was shown that the mode of the ventilation fan operation which pressurizes the tunnel not under the fire and ventilates the smoke from the tunnel under the fire is most effective for the smoke control in the tunnel in case of the fire occurrence. It was also shown that the blowing of jet fan from the rescue tunnel to the main tunnel should be in the same direction as the flow direction in the main tunnel arising from the traffic and the buoyancy.