This paper summarizes a design procedure of radiated noise from engine blocks of marine engines. This air-borne noise is one of the significant noise contributors including the aeroacoustic noise due to intake and exhaust and the re-radiation due to structure-borne noise. Excitation forces by engine operations are evaluated taking into account the power generation mechanism from the burning process to the subsequence motion of internal parts; piston, connecting rod, and crank shaft. The acoustic transfer vector method is incorporated to effectively simulate the radiated noise field under the various operation conditions. A contribution analysis for the various excitations to the radiated noise is conducted. It is found that the firing pressure is the main source of the radiated noise, and so the structure of the cylinder can be modified to significantly reduce the radiated noise from the engine block.