In order to establish detailed plans for fire protection and reduce the possible fire accidents in the future, a study on the shock wave caused by VCE(Vapor Cloud Explosion) is very important. Destruction phenomena of structure by gas explosion is due to the explosion pressure and heat. Explosion pressure is a kind of energy converted from the gas mixture explosion. Therefore, the propagation progress of shock wave and flame is very important. This study investigated the shock wave caused by VCE in enclosure with opened vent port. From a result, the vent port of top at the straight line of ignition and leak location was opened most rapidly, and the vertical vent port not opened.