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일개 농촌지역의 초등학생과 주민에서 다환성 방향족 탄화수소와 톨루엔 노출이 요중 Thiobarbituric Acid Reactive Substance 농도에 미치는 영향
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  • 일개 농촌지역의 초등학생과 주민에서 다환성 방향족 탄화수소와 톨루엔 노출이 요중 Thiobarbituric Acid Reactive Substance 농도에 미치는 영향
저자명
김대선,이철호,엄상용,강택신,김용대,김헌,Kim. Dae-Seon,Lee. Chul-Ho,Eom. Sang-Yong,Kang. Tack-Shin,Kim. Yong-Dae,Kim. Heon
간행물명
Journal of preventive medicine and public health
권/호정보
2008년|41권 1호|pp.61-67 (7 pages)
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

Objectives : Polycyclic aromatic hydrocarbons (PAH) and toluene have been reported to induce reactive oxygen species and oxidative stress. This study was performed to investigate the effects of low level exposure to PAHs or toluene on the lipid peroxidation level in elementary school children and the elderly in a rural area. Methods : Forty seven elementary school children and 40 elderly people who were living in a rural area and not occupationally exposed to PAH or toluene were the subjects of this study. Information about active or passive smoking and diet was obtained using a self-administered questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2-naphthol, hippuric acid and thiobarbituric acid reactive substance (TBARS) concentrations were measured, and these values were corrected with the urinary creatinine concentration. Results : In school children, the geometric means of the urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels were $0.02;{mu}mol/mol$ creatinine, $0.47;{mu}mol/mol$ creatinine, 0.14 g/g creatinine and $0.95;{mu}mol/g$ creatinine, respectively. Those values for the elderly were $0.07{mu}mol/mol$ creatinine, $1.87{mu}mol/mol$ creatinine, 0.11 g/g creatinine and $1.18;{mu}mol/g$ creatinine, respectively. The mean levels of urinary 1-OHP, 2-naphthol and TBARS were significantly higher in the elderly subjects than in the children. The urinary TBARS level was not correlated with the urinary 1-OHP, 2-naphthol and hippuric acid, but they were correlated with the age of the subjects. Conclusions : These results suggest that low level inhalation exposure to PAH or toluene does not markedly increase lipid peroxidation, and age is a significant determinant of lipid peroxidation.