- Abstract - Objectives: The purpose of this paper is to determine an efficient operation plan for a smoking cessation clinic in public health centers. To do so, the primary success factors in smoking cessation have been analyzed after classifying the smoking cessation programs of public health centers into urban and rural areas. Methods: A study was conducted with 262,837 smokers age 19 or older who were provided with smoking cessation services for more than 6 months through smoking cessation clinics at public health centers(250 clinics nationwide) from July 16, 2006 to July 15, 2007. Results: Urban areas indicated that gender, age, social security, the frequency of counseling, re-enrollment in the program, the number of cigarettes per day and alcohol problems were all factors that influenced the success of smoking cessation. On the other hand, in the rural areas the total number of counseling, re-enrollment in the program, the number of cigarettes per day and alcohol problems were the influential factors. Furthermore, the urban area confirmed that the frequency of counseling, re-enrollment in the program, the number of cigarettes per day and alcohol problems affected traveling while the rural area was affected by social security, the frequency of counseling and re-enrollment. Conclusions: It has been confirmed that the success rate and factors of smoking cessation clinics can vary depending on the region and enrollment method.