Purpose: The purpose of this study was to identify effects of family support and quality of life on smoking cessation in patients with coronary artery disease. Method: Data were collected using a self-reported questionnaire included smoking history, family support and quality of life (QOL). The participants were 159 male patient with coronary artery disease who were current smokers or ex-smokers. A logistic model was developed to estimate the likelihood of current smoker or ex-smoker. Results: Of the participants, 28.3% were current smokers and 71.7% were ex-smokers. The mean score for family support was 27.41 for positive support and 23.11 for negative support. The mean score for QOL was 50.48. There were significant differences in QOL according to smoking status. The predictors of smoking cessation were social interaction QOL and self-control QOL, and duration of smoking. The model correctly classified 89.5% of ex-smokers and 44.4% of current smokers and the correct classification for the total was 76.8%. Conclusion: Social interaction QOL, self-control QOL and duration of smoking were significant variables in prediction of smoking cessation. QOL should be considered in developing smoking cessation interventions. It is advisable to also examine the mediating effect of family support on quality of life.