A transmission designed with P.T.O(Power Take-Off) axle for agricultural work vehicles including multi-purpose vehicles has been developed. It is focused on the 4-wheel drive transmission of synchronous contact type for practical use in fruit tree households which is required for a large-sized agricultural vehicle. Concerning to the specification performed, the load capacity is from 500kg to 1,000kg and the safety should be secured for passengers. In addition, the driving condition should also be secured under bad situations of the topographic slope, swampy land and the rest. In order to carry out above tests, a prototype vehicle through strength analysis of transmission design has been manufactured. Consequently, optimal design conditions on the power transmission with multi-purpose vehicle for various jobs are proposed such as an indication of optimal RPM and torque at a certain work situation. The performance test through the prototype of multi-purpose work vehicle is performed and the related data base is achieved. Finally, it is improved on troubles by the analysis of the results of R&D and provided the solutions on problems occurring to mass production in the future.