Poly(vinyl alcohol)/sericin(PVA/sericin) blend fiber was prepared successfully using lithium chloride/dimethylsulfoxide(LiCl/DMSO) solvent system. Sericin could be dissolved up to 30% (w/v) in 1 M LiCl/DMSO solvent. The concentration of the dope solution and the blend ratio affect critically on the spinnability of PVA/sericin blend fiber. The high content of sericin in PVA/sericin blend fiber was achieved and it was at least three times higher than previous researches. The secondary structure of PVA/sericin blend film was revealed by ATR FT-IR. The secondary structure of sericin was changed from random coil to ${eta}$-aggregate state by methanol.