Chimera grid methods have been widely used in Computational Fluid Dynamics due to its simplicity in constructing grid systems over complex bodies, and suitability for unsteady flow computations with bodies in relative motion. However, the interpolation procedure for ensuring the continuity of the solution over overlapped regions fails when the so-called orphan cells are present. We have adopted the MLS(Moving Least Squares) method to replace commonly used linear interpolations in order to alleviate the difficulty associated with the orphan cells. MLS is one of the interpolation methods used in mesh-less methods. A number of examples with MLS are presented to show the validity and the accuracy of the method.