When a circular cylinder is placed at the center of a slot burner nozzle, once stable Woflhard-Parker type laminar lean premixed flame is changed to an oscillating flame with self-induced noise. The wrinkled flame surface showed the same pattern and frequency of the Karman vortex street at the downstream of a circular cylinder. The interaction of flame with Karman vortex street is observed to be responsible for flame oscillation. The measured flame oscillation frequency is very similar to the estimated Karman vortex shedding frequency based on the St-Re relationship of the flow past circular cylinder, which could be considered as a strong evidence for the interaction between laminar pre-mixed flame and a Karman vortex street. As Reynolds number increases oscillation frequency decreases and the self-induced noise level increases as well as the flame front is more severly wrinkled. This result suggests that the flame/vortex interaction becomes more active at higher Re.